Cytotec drug has gastroprotective and antiulcer action. The drug is designed for the treatment and prophylaxis of ulcerative diseases. Cytotec medication is produced in tablets for oral use. Each tablet contains active substance Misoprostol, which is a synthetic analogue of prostaglandin E1.

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 Misoprostol belongs to pharmacological group of prostaglandins, thromboxanes, leukotrienes and their antagonists.

Cytotec increases the resistance of gastric mucosa and provides healing of peptic ulcers. Also the drug prevents development of erosive and ulcerative lesions. Therefore Cytotec can be prescribed not only for the treatment but prevention of ulcerative states as well. Moreover Cytotec drug can reduce a risk of gastric and duodenal ulcers as well as the risk of ulcerative bleeding in patients, taking non-steroidal anti-inflammatory drugs.

Cytotec drug has antisecretory activity. Mechanism of Cytotec action is based on inhibition of basal, nighttime and stimulated secretion of gastric juice and hydrochloric acid. Cytotec drug enhances the formation of bicarbonate and mucus, improving the blood flow and reducing basal (not stimulated by histamine) production of pepsin.

 Having anti-secretory effect, Cytotec medication prevents damaging of mucous membrane in the gastrointestinal tract, significantly reducing the risk of gastric and (or) duodenal ulcer.

 Oral Cytotec tablets are quickly dissolved and well absorbed into the gastrointestinal tract. The onset of therapeutic effect of Cytotec tablets depends on time of meals, ranging 8 to 80 minutes. Inhibition of gastric acid secretion and reducing of gastric juice acidity occurs within:

 -        8-14 minutes after oral intake of Cytotec tablets on an empty stomach;

-        15-20 minutes after oral intake of Cytotec tablets together with antacids (such as: Foamcoat, Gaviscon, Foamicon, Actonel with calcium);

-        60-80 minutes since the intake of Cytotec tablets after eating foods rich in animal and (or) vegetable fats.

 Common duration of Cytotec pills pharmacological action depends on time of intake (before or after food) and does not exceed 180 minutes as a rule. Note that Cytotec medication not only has antisecretory effect, but also:

 -        causes mild stimulating effect on the smooth muscles of the gastrointestinal tract;

-        induces the contraction of smooth muscle fibers in the myometrium;

-        stimulates the expansion of the uterine cervix

Clinical effectiveness of antiulcer Cytotec medication

According to short-term clinical trials, the risk of damaging the mucous membrane in the duodenum and (or) stomach is reduced by 70-90% with:

 -        the use of NSAID Naproxen or NSAID Tolmetin in combination with Cytotec 200mcg pill, 4 times a day;

-        the use of NSAID Aspirin and Cytotec pills, 4 times a day (a single dose of Cytotec varies from 25mcg to 200mcg);

-        the use of NSAID Ibuprofen and Cytotec pills, 4 times a day (a single dose of Cytotec varies from 100mcg to 200mcg).

Cytotec medication is used as medical and prophylaxis means in the following gastrointestinal diseases:

 -        erosion of the mucosa in the gastrointestinal tract;

-        ulcerative disease of the stomach and duodenum;

 To prevent peptic ulcer disease, the antiulcer drug Cytotec can be prescribed to children and adults, taking:

 -        glucocorticosteroids (Mometasone, Elocon, Novasone, Nasonex, Fluticasone, Avamys, Flixonase, Flixotide, Ciclesonide, Alvesco, Omnaris);

-        anticoagulants (Coumadin, Warfarin, Marevan, Dindevan, Phenindione).

 Cytotec Dose Regime

•   Cytotec dose regimen is determined individually according to type of the disease and individual patient tolerance to drugs.
•    Cytotec 100 mcg pill has to be taken by mouth without chewing or crushing it (take it with water during meal time).
•    Cytotec tablet should be taken during meals with water to ease swallowing. Herewith the last daily dose of Cytotec should be taken right before sleep.
•    Usually to treat erosive gastritis and ulcerative disease of the stomach and duodenum as well as to prevent ulcers with NSAIDs, it is recommended to take Cytotec 200 mcg twice or four times a day.
•    The intake frequency depends on type of the disease. Maximum daily dose of Cytotec is 800 mcg. It is not recommended to exceed the maximum allowable dose of Cytotec, because it increases the risk of side effects.
•    If patient’s state indicates poor tolerance to Cytotec 800 mcg per day, then Cytotec dose has to be reduced to 400 mcg.
•    Patients with renal impairment may need to reduce Cytotec dose up to the minimum. However, the necessity to reduce the dose is determined individually, since Cytotec is tolerated well in most cases.

Cytotec drug can interact with other medications.

-        When used together with antacids, Cytotec reduces the concentration of Misoprostol in the blood plasma.

-        When used together with magnesium-containing antacids, Cytotec can enhance the diarrheal effect.

-        Combined use of Cytotec with Diclofenac and Indometacin may increase side effects of Diclofenac and Indometacin.

-        Acetylsalicylic acid and Cimetidine accelerate biotransformation of Misoprostol, reducing its amount in the blood.

-        Combined use of Lornoxicam and Cytotec can provoke reduce side effects from gastrointestinal tract.

-        Rifampicin accelerates the biotransformation of Cytotec and eases therapeutic effect of the drug.

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